Kyren Williams anchored the night for the Rams with a versatile, dual-threat performance, while Christian McCaffrey and Puka Nacua supplied the top fantasy fire for SF and LA. Kendrick Bourne flashed a breakout line (10-for-142) and signaled a renewed connection with Mac Jones, amplified by Kyle Shanahan’s scheming. Brock Purdy stayed efficient under pressure, and SF’s receiving corps looked healthier with Jauan Jennings and George Kittle looming as weekly ceiling raisers.

Thursday night’s Rams-49ers showdown centers on injury updates, QB uncertainty, and the ripple effects on both sides’ offenses. Stafford must navigate SF’s front without overcommitting, while McCaffrey and the Rams’ dynamic receiving trio test a banged-up secondary. Puka Nacua’s versatility and Davante Adams’ presence give Los Angeles dangerous options in the short-to-intermediate game. San Francisco counters with run-first rhythm, Brock Purdy or M. Jones at the helm, and a defense missing Nick Bosa, seeking to turn the tide with pressure and scheme.

Front-seven battles and special-teams swing potential fuel the storyline. The Rams’ pass rush, led by Verse and Byron Young, aims to disrupt the SF attack, while the 49ers try to rekindle their hallmark run game and leverage play-action. The outcome hinges on execution in the trenches, clock management, and which team can capitalize on the opponent’s injuries in a primetime setting.

Rams visit San Francisco in a short-week showdown as Stafford looks to sharpen his timing behind a healthier but still taxed offense. San Francisco must cope without Nick Bosa for some snaps, while McCaffrey remains a constant weapon in a high-volume role. Puka Nacua’s versatility and DeMarcus Robinson’s potential renewed involvement give L.A. multiple paths to produce fantasy-relevant receivers. The 49ers’ run game stalls without big plays, so push from the Rams’ front and interior pressure will be critical.

Key matchup notes: Rams’ pass rush (Vers, Byron Young) vs. SF’s shaky offensive line, and WR mix (Nacua, Adams, Bourne, Robinson) in a game where red-zone efficiency could decide the outcome. Special teams and game tempo could swing a close tilt; line movement hints at confidence in L.A. If SF can bottle McCaffrey and pressure Purdy, the Rams have a real shot to steal a road win on Thursday night.

Fantasy take: with Bosa out, SF’s defense could yield more chunk plays for Rams receivers. Expect a heavy McCaffrey workload for SF, but if Purdy plays and SF moves the chains, Stafford may need volume to reach fantasy upside. Monitor practice reports for the latest on line health and which Rams receivers step up in a potential shootout.